Generic name: Pefloxacin Mesylate Dihydrate
400 mg
Manufactured by:
Unit Price: ৳ 15.38, (20's pack: ৳ 307.60)
Pefloxacin is indicated in adult for the treatment of single infection or mixed infections caused by two or more susceptible microorganisms. It can also be used for infections caused by organisms resistant to other antibiotics. Pefloxacin is indicated to the following manifestations:
- Gastrointestinal infection … Read more
Pefloxacin is indicated in adult for the treatment of single infection or mixed infections caused by two or more susceptible microorganisms. It can also be used for infections caused by organisms resistant to other antibiotics. Pefloxacin is indicated to the following manifestations:
- Gastrointestinal infection: Enteric fever, acute bacterial diarrhoea & chronic Salmonella carriers.
- Urinary tract infection: Cystitis, pyelonephritis, prostatitis, epididymitis, uncomplicated and complicated urethritis.
- Respiratory tract infection: Pneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis, empyema.
- Ear, nose and throat infection: Otitis media, otitis externa, sinusitis, tonsillitis.
- Bone and joint infection: Osteomyelitis, arthritis.
- Skin and soft tissue infection: Infected ulcer, wound infection, abscess, cellulitis, erysipelas and infected burn.
- Pelvic infection: Salpingitis, endometritis, pelviperitonitis.
- Abdominal and hepatobiliary infection: Peritonitis, intra abdominal abscess and cholingitis, cholecystitis and empyema of the gall bladder.
- Also used in septicemia, bacteraemia, gonorrhoea, endocarditis, meningitis.
Pefloxcin is a synthetic antibacterial agent, belongs to fluoroquinolone group. It exerts its action by inhibiting the subunit-A of DNA gyrase (Topoisomerase II). Pefloxcin is bactericidal and has a broad spectrum of activity.
When taken concomitantly with an Antacid containing Aluminium and/or Magnesium Hydroxide gel, absorption of Pefloxacin is reduced. So, concurrent administration of these agents with Pefloxacin should be avoided.
Occasionally observed reactions are – Gastrointestinal disturbance: Epigastric pain, nausea, vomiting, diarrhoea, dyspepsia. Central nervous system disturbance: Headache, insomnia. Hypersensitivity reaction: Skin rash, pruritis, photosensitization. Others: Myalgia and/or arthralgia, tendonitis, rupture of achilles tendon.
Pefloxacin has been assigned to pregnancy category C by the FDA.
Because of the risk of photosensitivity reaction, exposure to sunlight and ultraviolet radiation should be avoided during Pefloxacin therapy. Dosage readjustment is required in severe hepatic insufficiency. Patients should be informed of the possibility of pain in the achilles tendon.
4-Quinolone preparations
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
